The CanRisk Web Tool incorporates the new version of BOADICEA v5, the Breast and Ovarian Analysis of Disease Incidence and Carrier Estimation Algorithm.
BOADICEA is a comprehensive model that can be used to calculate the future risks of developing breast or ovarian cancer using information on family history, lifestyle/hormonal risk factors, rare pathogenic variants in moderate and high risk breast/ovarian cancer susceptibility genes, common breast/ovarian cancer genetic susceptibility variants (Polygenic Risk Scores) and mammographic density. It can also be used to calculate the likelihood of carrying mutations in the moderate to high risk genes BRCA1, BRCA2, PALB2, ATM and CHEK2.
NEW: Portuguese and Italian versions available by selecting 'pt' or 'it' in the menu bar.
NEW: optionally show genetic test and pathology data in the pedigree graphic.
NEW: zoom-in, out and scale-to-fit in the 'Family History' section to assist viewing pedigrees.